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Public release date: 7-Nov-2012[ | E-mail |
Share ] Contact: Jennifer Kohm
jkohm@cfri.ca
604-875-2401
Child & Family Research Institute
Discovery could lead to new treatment for lung inflammation
Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation. The finding offers a potential new drug target for treating CF lung disease, which is a major cause of illness and death for people with CF.
"Developing new drugs that target lung inflammation would be a big step forward," says Dr. Stuart Turvey, who led the research. Dr. Turvey is the director of clinical research and senior clinician scientist at the Child & Family Research Institute and a pediatric immunologist at BC Children's Hospital. He is an associate professor in the Department of Pediatrics at the University of British Columbia.
The research was published online last week in the Journal of Immunology.
For the study, researchers compared the immune response of normal lung cells with that of CF lung cells after exposing both types of cells to bacteria in the lab. In healthy cells, exposure to bacteria triggers the cell to secrete special molecules that attract immune cells to fight the infection.
In CF lung cells, the researchers discovered that a series of molecular events called the unfolded protein response is more highly activated. It causes the CF lung cells to secrete more molecules that attract an excessive amount of immune cells, which leads to increased inflammation.
They also found that treating the CF cells with a special chemical normalized the unfolded protein response and stabilized the cells' immune response.
CF is the most common genetic disease affecting young Canadians. One in every 3600 children born in Canada has CF. There is no cure. A build-up of mucus in the lungs causes people with CF to be susceptible to bacterial lung infections, which trigger inflammation and swelling. Over time, the recurring cycle of infections and inflammation damages the lungs and can lead to the need for lung transplantation. The only treatments for lung inflammation are steroids and anti-inflammatory medications, which can have significant side effects.
The researchers are planning further study to validate these findings in a larger number of lung cell samples from people with CF.
###
This discovery resulted from a collaboration among Vancouver investigators and trainees based at the Child & Family Research Institute at BC Children's Hospital, the University of British Columbia, and the Providence Heart + Lung Institute at St. Paul's Hospital.
This research was funded by Cystic Fibrosis Canada and the Michael Smith Foundation for Health Research.
The Child & Family Research Institute conducts discovery, translational and clinical research to benefit the health of children and their families. CFRI is supported by BC Children's Hospital Foundation and works in close partnership with the University of British Columbia, BC Children's Hospital, and BC Women's Hospital & Health Centre (agencies of the Provincial Health Services Authority). For more information, visit www.cfri.ca.
BC Children's Hospital, an agency of the Provincial Health Services Authority, is British Columbia's (B.C.'s) only pediatric hospital and home to many specialized pediatric services available nowhere else in the province, including B.C.'s trauma centre for children, pediatric intensive care, kidney and bone marrow transplants, open heart surgery, neurosurgery and cancer treatment. Sunny Hill Health Centre for Children is the provincial facility that offers specialized child development and rehabilitation services to children and youth. For more information, please visit www.bcchildrens.ca.
The University of British Columbia (UBC) is one of North America's largest public research and teaching institutions, and one of only two Canadian institutions consistently ranked among the world's 22 best universities. Surrounded by the beauty of the Canadian West, it is a place that inspires bold, new ways of thinking that have helped make it a national leader in areas as diverse as community service learning, sustainability and research commercialization. UBC offers more than 56,000 students a range of innovative programs and attracts $550 million per year in research funding from government, non-profit organizations and industry through over 8,000 projects and grants. For more information, please visit www.ubc.ca.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 7-Nov-2012[ | E-mail |
Share ] Contact: Jennifer Kohm
jkohm@cfri.ca
604-875-2401
Child & Family Research Institute
Discovery could lead to new treatment for lung inflammation
Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation. The finding offers a potential new drug target for treating CF lung disease, which is a major cause of illness and death for people with CF.
"Developing new drugs that target lung inflammation would be a big step forward," says Dr. Stuart Turvey, who led the research. Dr. Turvey is the director of clinical research and senior clinician scientist at the Child & Family Research Institute and a pediatric immunologist at BC Children's Hospital. He is an associate professor in the Department of Pediatrics at the University of British Columbia.
The research was published online last week in the Journal of Immunology.
For the study, researchers compared the immune response of normal lung cells with that of CF lung cells after exposing both types of cells to bacteria in the lab. In healthy cells, exposure to bacteria triggers the cell to secrete special molecules that attract immune cells to fight the infection.
In CF lung cells, the researchers discovered that a series of molecular events called the unfolded protein response is more highly activated. It causes the CF lung cells to secrete more molecules that attract an excessive amount of immune cells, which leads to increased inflammation.
They also found that treating the CF cells with a special chemical normalized the unfolded protein response and stabilized the cells' immune response.
CF is the most common genetic disease affecting young Canadians. One in every 3600 children born in Canada has CF. There is no cure. A build-up of mucus in the lungs causes people with CF to be susceptible to bacterial lung infections, which trigger inflammation and swelling. Over time, the recurring cycle of infections and inflammation damages the lungs and can lead to the need for lung transplantation. The only treatments for lung inflammation are steroids and anti-inflammatory medications, which can have significant side effects.
The researchers are planning further study to validate these findings in a larger number of lung cell samples from people with CF.
###
This discovery resulted from a collaboration among Vancouver investigators and trainees based at the Child & Family Research Institute at BC Children's Hospital, the University of British Columbia, and the Providence Heart + Lung Institute at St. Paul's Hospital.
This research was funded by Cystic Fibrosis Canada and the Michael Smith Foundation for Health Research.
The Child & Family Research Institute conducts discovery, translational and clinical research to benefit the health of children and their families. CFRI is supported by BC Children's Hospital Foundation and works in close partnership with the University of British Columbia, BC Children's Hospital, and BC Women's Hospital & Health Centre (agencies of the Provincial Health Services Authority). For more information, visit www.cfri.ca.
BC Children's Hospital, an agency of the Provincial Health Services Authority, is British Columbia's (B.C.'s) only pediatric hospital and home to many specialized pediatric services available nowhere else in the province, including B.C.'s trauma centre for children, pediatric intensive care, kidney and bone marrow transplants, open heart surgery, neurosurgery and cancer treatment. Sunny Hill Health Centre for Children is the provincial facility that offers specialized child development and rehabilitation services to children and youth. For more information, please visit www.bcchildrens.ca.
The University of British Columbia (UBC) is one of North America's largest public research and teaching institutions, and one of only two Canadian institutions consistently ranked among the world's 22 best universities. Surrounded by the beauty of the Canadian West, it is a place that inspires bold, new ways of thinking that have helped make it a national leader in areas as diverse as community service learning, sustainability and research commercialization. UBC offers more than 56,000 students a range of innovative programs and attracts $550 million per year in research funding from government, non-profit organizations and industry through over 8,000 projects and grants. For more information, please visit www.ubc.ca.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-11/cfr-ndt110712.php
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